I. Wellbutrin SR Fact File
Wellbutrin SR was introduced by GlaxoSmithKline (GSK) Pharmaceuticals.
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company. Glaxo is headquartered in the UK and with operations based in the US, the new company is one of the industry leaders, with an estimated seven per cent of the world's pharmaceutical market.
GSK also has leadership in four major therapeutic areas - anti-infectives, central nervous system (CNS), respiratory and gastro-intestinal/metabolic. In addition, it is a leader in the important area of vaccines and has a growing portfolio of oncology products.
Glaxo also has a Consumer Healthcare portfolio comprising over-the-counter (OTC) medicines, oral care products and nutritional healthcare drinks, all of which are among the market leaders.
II. Wellbutrin SR Medication
Wellbutrin SR medication helps reduce your cravings for cigarettes. The way it does this is not entirely known. Generic Wellbutrin SR does not contain nicotine and does not help you quit smoking in the same way that nicotine replacement therapy does.
Generic Wellbutrin SR is approved for use in people who smoke 10 or more cigarettes a day and are at least 18 years old. It is recommended for people who prefer a product that does not contain nicotine and for those who tried using a nicotine replacement product, such as a patch, nasal spray, gum, or inhaler, without success.
Wellbutrin SR medication may also be used for quitting smoking. Generic Wellbutrin SR is also used to treat depression. Wellbutrin SR medication works by helping to restore the balance of natural chemicals in the brain.
Generic Wellbutrin SR (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, Selective serotonin re-uptake inhibitor, or other known antidepressant agents.
Generic Wellbutrin SR increases the amount of two chemicals in the brain, norephineprine and dopamine.
Antidepressants: Information
Antidepressants are medication that relieve the symptoms of depression. They were first developed in the 1950s and have been used regularly since then. There are almost thirty different kinds of antidepressants available today and there are three main types:
- Tricyclics
- MAOIs (Monoamine oxidase inhibitors)
- SSRIs (Selective Serotonin Reuptake Inhibitors)
- SNRIs (Serotonin and Noradrenaline Reuptake Inhibitors)
Antidepressants works by altering the way in which certain chemicals work in our brains. These chemicals are made by our body and are called neuro-transmitters. They pass signals from one brain cell to another.
In depression, Many of the neurotransmitter systems, particularly those of Serotonin and Noradrenaline, do not seem to be working properly. We think that antidepressants work by increasing the activity of these chemicals in our brains.
After 3 months of proper treatment, the proportions of people with depression who will be much improved are 50% and 65% if given an antidepressant compared with 25 - 30% if given an inactive "dummy" pill, or placebo.
The older medication (Tricyclics) are just as effective as the newer ones (SSRIs) but, on the whole, the newer ones seem to have fewer side-effects. A major advantage for the newer medication is that they are not so dangerous if someone takes an overdose.
Depression: Information
Some clinical depression is a common, yet serious, illness that affects more than 19 million Americans each year.
Unfortunately, no more then one-third of sufferers seek treatment even though the illness can be effectively treated in 80 percent of all cases. Although depression is a real medical illness, many people still mistakenly believe it is a personal weakness.
Symptoms of Depression
The symptoms of clinical depression can vary from person to person. These symptoms can range from mild to severe and the causes of depression can often be complex.
If you have been experiencing five (5) or evenmore of the below symptoms for more than two (2) weeks, if suicide is a serious concern, or if the symptoms are severe enough to interfere with a daily routine -- seek medical advice or see your doctor or qualified mental health professional.
- Persistent sad, anxious or "empty" mood
- Sleeping too much or too little; middle-of-night or early-morning waking
- Reduced appetite and weight loss, or increased appetite and weight gain
- Loss of pleasure and interest in activities once enjoyed, including sex
- Irritability, restlessness
- Persistent physical symptoms that do not respond to treatment (such as chronic pain or digestive disorders)
- Difficulty concentrating, remembering or making decisions
- Fatigue or loss of energy
- Feeling guilty, hopeless or worthless
- Thoughts of death or suicide
Causes of Depression
For a number of people, a combination of many factors may be causing clinical depression. For others, a single factor may be triggering the illness. Depression often is related to the following.
- Imbalance of brain chemicals called neurotransmitters -
Changes in these brain chemicals may cause or contribute to clinical depression.
- Certain diseases or illnesses -
Ailments such as cancer, heart disease, Parkinson's disease, Alzheimer's disease, diabetes and hormonal disorders can often trigger clinical depression. This is referred to as co-occurring depression.
- Negative thinking patterns -
Some people who are pessimistic, have low self-esteem, worry excessively, or feel they have little control over life events are more likely to develop clinical depression.
- Family history of depression – A genetic history of clinical depression can increase one's risk for developing the illness. But depression also occurs in people who have had no family members with depression.
- Difficult life events – Events such as the death of a loved one, divorce, financial strains, history of trauma, moving to a new location or significant loss can contribute to the onset of clinical depression.
- Certain medications – Some medication can actually cause clinical depression. Therefore, it is important that people inform their doctors of all medications they are taking and report any depressive symptoms.
- Frequent and excessive alcohol consumption – Drinking large amounts of alcohol on a regular basis can sometimes lead to clinical depression. Excessive alcohol consumption is also sometimes a symptom of depression.
Side effects of Antidepressants
Tricyclics
These commonly cause a dry mouth, a slight tremor, fast heartbeat, constipation, sleepiness, and weight gain. Particularly in older people, they may cause confusion, slowness in starting and stopping when passing water, faintness through low blood pressure, and falls. If you have heart trouble, it may be best not to take one of this group of antidepressants. Men may experience difficulty in getting or keeping an erection, or delayed ejaculation. Tricyclic antidepressants are dangerous in overdose.
SSRIs
During the first couple of weeks of taking them, you may feel sick and more anxious. Some of these medication can produce nasty indigestion, but you can usually stop this by taking them with food. More seriously, they may interfere with your sexual function. There have been reports of episodes of aggression, although these are rare.
Some people get a small number of mild side-effects (if any). The side effects usually wear off over a couple of weeks as your body gets used to the medication. It is important to have this whole list, though, so you can recognize side effects if they happen. You can then talk them over with your doctor.
The more serious side effects are problems with urinating, difficulty in remembering, falls, confusion - are uncommon in healthy, younger or middle-aged people. It is common, if you are depressed, to think of harming or killing yourself. Tell your doctor - suicidal thoughts will pass once the depression starts to lift.
SNRIs
The side effects are very similar to the SSRIs, but, Effexor (Venlafaxine) is not recommended for people who have heart problems, high blood pressure or problems with the salt levels in their blood. They can be helpful if other antidepressants have failed but they should only be prescribed by doctors with special experience in mental health.
MAOIs
This type of antidepressant is rarely prescribed these days. MAOIs can give you a dangerously high blood pressure if you eat foods containing a substance called Tyramine. If you agree to take an MAOI antidepressant your doctor will give you a list of foods to avoid.
Uses of Antidepressants
- Moderate to severe depressive illness (Not mild depression)
- Severe anxiety and panic attacks
- Obsessive compulsive disorders
- Chronic pain
- Eating disorders
- Post-traumatic stress disorder.
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III. Useful links
Government http://www.cdc.gov/
http://www.fda.gov/
http://www.fda.gov/cder/ogd/
http://www.nih.gov/
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
http://www.health.gov.on.ca/
National Library of Medicine
World Health Organization
Health Sites
http://www.mayoclinic.com/index.cfm
MedicineNet.com
Drugdigest.org
Healthsquare.com
About.com Health section
Pharmacy sites http://www.gsk.com
http://www.hsforum.com/stories/storyReader$1509
http://www.hsforum.com/stories/storyReader$1516
http://www.hsforum.com/stories/storyReader$1504
http://www.people.vcu.edu/~urdesai/atc.htm#Process%20of%20clotting
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