Zyban SR and its Uses
Generic Zyban SR belongs to the family of medication known as antidepressants. Generic Zyban SR used to help people who are dependant on nicotine to give up smoking. Generic Zyban SR acts in the brain but is not the same as nicotine replacement therapy.
|| Top || Working Mechanism of Zyban SR
Generic Zyban SR is not fully understood how this medicine works to help people give up smoking, but it is known that Zyban SR affects neurotransmitters in the brain. Generic Zyban SR affects neurotransmitters in the brain. Neurotransmitters are chemicals that are stored in nerve cells and are involved in transmitting messages between the nerve cells.
Neurotransmitters are discharged from nerve cells as a message is transmitted. Once the message has been transmitted, the nerve cells then reabsorb the neurotransmitter.
Generic Zyban SR prevents two of these neurotransmitters, noradrenaline and dopamine, from being reabsorbed back into the nerve cells. Noradrenaline and dopamine are responsible for moderating mood and various other processes in the brain.
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Zyban SR Dose
Missed Dose of Zyban SR
Skip the missed dose of Zyban SR and take only your next regularly scheduled dose. Do not take a double dose of Zyban SR .
Excess Dose of Zyban SR
Generic Zyban SR in excess dose may show symptoms such as seizures, hallucinations, loss of consciousness, weakness, a fast heartbeat, and heart attack.
Conditions for Storage of Generic Zyban SR
Store Generic Zyban SR at room temperature away from moisture and heat.
Potencies of Generic Zyban SR
Zyban SR Tablets: Zyban SR 150 mg
|| Top || Food and Drug Interactions with Zyban SR Dose
- There is a rare risk of seizures (fits) occurring with Generic Zyban SR. This risk is greater if you take other medicines that can increase the likelihood of seizures in combination with Zyban SR. These include the following:
- antipsychotics to treat mental illness
- antidepressants
- steroids taken by mouth or injection
- theophylline
- antimalarials
- tramodol
- quinolone antibiotics, e.g. ciprofloxacin, ofloxacin
- sedating antihistamines
- stimulants
- slimming medicines
- Generic Zyban SR must not be taken by people taking monoamine oxidase inhibitor antidepressants (MAOIs). At least 14 days should pass after stopping an MAOI (e.g. phenelzine, tranylcypromine, isocarboxazide) before starting treatment with Generic Zyban SR.
- Generic Zyban SR may increase blood levels of the following medicines. As this may result in an increased risk of side effects, your doctor may decrease the dose of these medicication if you are taking them with Zyban:
- certain antidepressants, e.g. desipramine, imipramine, paroxetine
- antipsychotics, e.g. thioridazine, risperidone
- beta-blockers, e.g. metoprolol
- medicines for abnormal heart rhythm, e.g. flecainide, propafenone
- The following mediciation may affect the blood level of Generic Zyban SR:
- carbamazepine
- phenobarbitone
- phenytoin
- sodium valproate
- cyclophosphamide
- ifosfamide
- orphenadrine
- cimetidine
- There may be an increase in side effects if Zyban SR is taken with levodopa (for Parkinson's disease).
- The components of tobacco smoke can cause certain medication to be removed from the body faster than normal. When you stop smoking, they are removed slower, so their blood levels may increase. Tell your doctor you are giving up smoking if you take any medicines, in particular:
- theophylline
- tacrine
- clozapine
- olanzapine
- pentazocine
- some benzodiazepines, e.g. oxazepam
- some beta-blockers, e.g. propranolol
- flecainide
- tricyclic antidepressants, such as imipramine
- fluvoxamine
- phenylbutazone
- dextropropoxyphene
- People with diabetes who smoke normally need more insulin, as smoking reduces the amount of insulin that is absorbed into the blood from an injection under the skin. Therefore if people with diabetes give up smoking, they may subsequently need a reduction in their insulin dose.
- Using nicotine replacement therapy in combination with Generic Zyban SR is not currently recommended. However, if it is used with this medicine, your blood pressure should be monitored weekly.
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Contraindications with Zyban SR
Generic Zyban SR is contraindicated in the following:
- Seizure disorders, e.g. due to brain injury or epilepsy
- History of fits (seizures), e.g. epilepsy
- Tumors of the brain or spinal cord (central nervous system)
- People undergoing abrupt withdrawal from alcohol or benzodiazepines (e.g. diazepam, temazepam)
- People with a history of anorexia nervosa
- People with a history of bulimia nervosa
- Severe cirrhosis of the liver
- People who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days
- People with a history of bipolar disorder (manic depression)
- Breastfeeding
- Pregnancy
- People taking any other medicinal product that contains Generic Zyban SR
- Zyban SR is not recommended for children and adolescents under 18 years of age, as there is no information regarding its safety and efficacy in this age group.
- Allergy to one or any of its ingredients
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Precautions with Zyban SR
Generic Zyban SR should be used with caution in:
- Elderly people
- Decreased kidney function
- Decreased liver function
- Alcohol abuse
- People who have had a head injury
- People taking medicines known to increase the risk of seizures (see below)
- Diabetes
- History of psychiatric illness
- High blood pressure
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Adverse effects with Zyban SR
The adverse effects associated with Generic Zyban SR are:
- Difficulty in sleeping (insomnia)
- Headache
- Concentration disturbance
- Tremor
- Dizziness
- Anxiety and agitation
- Depression
- Dry mouth
- Disturbances of the gut such as constipation, nausea, vomiting or abdominal pain
- Fever (pyrexia)
- Sweating
- Rash or itching
- Increased heart rate (tachycardia)
- Increased blood pressure
- Loss of appetite
- Visual disturbances
- Chest pain
- Seizures
- Hypersensitivity reactions such as narrowing of the airways (bronchospasm), swelling of the lips, throat and tongue (angioedema), itchy blistering rash or anaphylactic shock
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