Evista and its Uses
Generic Evista is used for the prevention and treatment of osteoporosis in women after menopause.
Generic Evista is neither an estrogen nor a hormone. Generic Evista is a Selective Estrogen Receptor Modulator, or SERM. Generic Evista helps build bone without negatively affecting the breast or uterus.
Generic Evista reduces the amount of calcium lost from bones. Generic Evista helps to prevent bone loss and to increase normal healthy bone formation in patients with osteoporosis. Generic Evista does not reduce hot flashes associated with estrogen deficiency.
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Oestrogen, the main female hormone, has many actions throughout the body. Bone tissue, cholesterol metabolism, breast tissue and uterine tissue are all affected by this hormone. At the menopause, blood levels of oestrogen start to decrease and this affects the tissues that are normally responsive to oestrogen.
In terms of bone tissue, declining levels of oestrogen result in an increase in bone breakdown, which can lead to a loss of bone density. Bone loss is particularly rapid for the first ten years after the menopause and it may lead to the development of osteoporosis - a condition in which the bones are weak and break more easily.
Generic Evista is used to both prevent and treat osteoporosis in postmenopausal women. Generic Evista works by acting on oestrogen receptors in the bone tissue, where Generic Evista mimics the natural effects of oestrogen. This gradually reverses the excessive breakdown of bone that happens at menopause and causes an increase in bone mineral density, making bones stronger. Generic Evista has been shown to significantly reduce the risk of spinal fractures, but not hip fractures.
Generic Evista selectively mimics the effects of oestrogen on bone tissue, but does not affect breast tissue or uterine tissue. This means that long-term use does not carry the increased risk of cancer of the lining of the womb (endometrial cancer) or breast cancer that is associated with long-term use of oestrogen-based hormone replacement therapy (HRT). However, raloxifene is associated with an increased risk of developing blood clots in the veins (venous thromboembolism). This risk is similar to that associated with hormone replacement therapy (HRT).
Due to its selective activity, Generic Evista is not effective at relieving other symptoms of oestrogen deficiency that occur during the menopause, for example hot flushes.
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Evista Dose
Missed Dose of Evista
Take the missed dose of Evista as soon as you remember. However, if it is almost time for the next dose of Evista , skip the missed dose and take only the next regularly scheduled dose of Evista . Do not take a double dose of Evista.
Excess Dose of Evista
Generic Evista in excess dose does not show any symptoms.
Conditions for Storage of Generic Evista
Store Generic Evista at room temperature away from moisture and heat.
Potencies of Evista
Evista Tablets: Evista 60 mg
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Food and Drug interactions with Evista
- Generic Evista has not been studied in combination with medicines used to treat breast cancer, and it is not known what effect it might have on these medicines. For this reason, women with breast cancer should only take Evista after their breast cancer treatment has been completed.
- Generic Evista should not be taken with oestrogen-containing medicines.
- The following medicines reduce the absorption of Generic Evista from the gut and should not be taken at the same time as Evista:
- cholestyramine
- colestipol
- Generic Evista may reduce the blood-thinning effect of anticoagulant medicines such as Coumadin (Warfarin). People taking an anticoagulant should have their blood clotting time checked after starting treatment with Evista; any effect on blood clotting time may develop over several weeks.
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Contraindications with Evista
Generic Evista is contraindicated in the following:
- Cancer of the lining of the womb (endometrial cancer)
- Decreased liver function
- Failure of the normal flow of bile from the liver to the intestines (cholestasis)
- Severely decreased kidney function
- People with a blood clot in the veins or a history of this, e.g. blood clot in the leg (deep vein thrombosis), in the lungs (pulmonary embolism), or in the eye (retinal vein thrombosis)
- Vaginal bleeding of unknown cause
- Pregnancy
- Women who could become pregnant
- Breastfeeding
- Allergy to one or any of its ingredients
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Precautions with Evista
Generic Evista should be used with caution in:
- Breast cancer (Evista should only be used after treatment for breast cancer has been completed)
- People with risk factors for developing dangerous blood clots in the blood vessels, e.g. smoking, obesity, immobility, or a history of blood clot disorders
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Adverse effects with Evista
The adverse effects associated with Evista are:
- Headache
- Rash
- Abdominal pain
- Swelling of the legs and ankles due to excess fluid retention (peripheral oedema)
- Indigestion (dyspepsia)
- Nausea and vomiting
- Leg cramps
- Hot flushes
- Migraine
- Increased risk of abnormal blood clots within the blood vessels (thromboembolic disorders)
- Rise in blood pressure
- Decreased numbers of platelets in the blood
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