Buy Generic/Brand Phenergan

Phenergan and its uses
Phenergan belongs to the class of Phenothiazine antihistamines.

Phenothiazine derivative antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body.

Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some persons histamine can close up the bronchial tubes (air passages of the lungs) and make breathing difficult.

Phenergan is also used to prevent motion sickness, nausea, vomiting, and dizziness. In addition, some of the anti-histamines may be used to help people go to sleep and control their anxiety before or after surgery.

Phenergan is derived from a group of medicines called phenothiazines, however, it is also part of the family of sedating antihistamines.

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Working Mechanism of Phenergan
Histamine is a chemical in the body that causes the symptoms of an allergic reaction. These can include inflammation of the skin, airways or tissues, rashes, itching of the skin, eyes or nose, nasal congestion and narrowing of the airways. Phenergan blocks the binding of histamine to receptors in many areas of the body and thereby prevents the actions of histamine. This helps prevent and relieve the typical symptoms of an allergic reaction.

Histamine may be released from and act in a small (localized) area of the body e.g. the nose. Alternatively, histamine can result in a serious or complete body reaction e.g. anaphylactic reaction. Phenergan is useful for the prevention or relief of localized or less serious allergies such as hay fever or itchy rash in addition to serious allergic reactions such as anaphylaxis.

Phenergan blocks histamine receptors in an area of the brain called the vomiting centre. It also acts to block other receptors in the vomiting centre (serotonin receptors). Therefore Phenergan prevents the vomiting centre from sending the nerve messages to the stomach that would normally result in vomiting. Phenergan also acts on receptors in the gut (muscarinic receptors) to decrease the amount of fluid secreted from the lining of the gut and decrease the actions of the gut muscles. This further aids the treatment or prevention of nausea and vomiting.

Phenergan is known as a sedating antihistamine as it enters the brain in significant quantities and causes drowsiness. As a result it is commonly used for the short-term treatment of sleep disturbances and to provide sedation prior to minor procedures or surgery.

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Phenergan Dose
You can take Phenergan with or without food.

Missed dose of Phenergan

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Excess dose of Phenergan

Signs and symptoms of a Phenergan overdose range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. There may be severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, and difficulty in breathing.

Conditions for storage of Phenergan

Store Phenergan at room temperature away from moisture and heat. Keep Phenergan and out of reach of children. Throw away Phenergan that is outdated or no longer needed.

Potencies of Phenergan

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Food and Drug Interactions with Phenergan

• It is recommended to avoid taking Phenergan if a monoamine oxidase inhibitor (MAOI) antidepressant (e.g. phenelzine) has been taken within the last 14 days.
• Before taking Phenergan, tell your doctor if you are taking any of the following medicines:
  • medications for depression such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil);
  • narcotics (pain killers) such as: meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others);
  • other sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal) and secobarbital (Seconal); or any other medications that make you feel drowsy, sleepy, or relaxed.
• The sedative effects of Phenergan may be increased by alcohol or other medicines which cause drowsiness e.g. alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion). It is recommended to avoid the consumption of alcohol when taking Phenergan.

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Contraindications with Phenergan

• Phenergan is contraindicated for use in pediatric patients less than two years of age.
• Phenergan should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
• Phenergan is contraindicated in comatose states (unresponsive unconscious states), and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines such as chlorpromazine and prochlorperazine.
• Phenergan should not be used in case of reduced awareness, slow reactions or drowsiness due to medicines or illness that reduce activity in the entral nervous system.
• Phenergan is contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.

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Precautions with Phenergan

• Phenergan should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
• Phenergan may interfere with some pregnancy tests, causing false negative or false positive results.
• Phenergan should be discontinued at least 72 hours before allergy skin tests, as it may cause false negative results.
• Avoid exposure to strong sunlight while taking Phenergan.
• Phenergan is only intended for the short-term treatment of insomnia.
• Phenergan should be used with caution in
  • Asthma
  • Blockage of the area where the stomach joins the intestines (pyloro-duodenal obstruction)
  • Blockage of the drainage passage of the bladder (bladder neck obstruction)
  • Bronchitis
  • Closed angle glaucoma
  • Decreased kidney function
  • Epilepsy
  • Severe coronary artery disease
  • Widening of the airways which may be hereditary or due to infection (bronchiectasis)

Phenergan can be used with caution during pregnancy. However, it should not be used in the last two weeks of pregnancy due to the risk of adverse effects the baby may experience. Seek medical advice from your doctor.

Small amounts of Phenergan may pass into breast milk. There are risks of harmful effects to the nursing infant. Seek medical advice from your doctor.

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Adverse effects with Phenergan
The following are some of the adverse effects that are known to be associated with Phenergan. Because a side effect is stated here, it does not mean that all people using phenergan will experience that or any side effect.

• Headache
• Blurred vision
• Difficulty in passing urine (urinary retention)
• Dry mouth
• Tiredness
• Drowsiness
• Confusion
• Nightmares
• Blood disorders
• Restlessness
• Abnormal reaction of the skin to light, usually a rash (photosensitivity)
• Dizziness
• Abnormal movements of the hands, legs, face, neck and tongue, e.g. tremor, twitching, rigidity (extrapyramidal effects)
• Unexpected increase in excitability (paradoxical hyperexcitability)

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