 |
Avelox and its Uses
Fast-acting and reliable, Generic Avelox (moxifloxacin), a fluoroquinolone, is a synthetic broad-spectrum antibacterial agent that has been approved for safe and effective treatment of respiratory tract infections (RTIs) in adults 18 years of age and older, including: Acute Bacterial Sinusitis (ABS), Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), and Community-Acquired Pneumonia (CAP).
Generic Avelox has a wide spectrum of activity that covers the key common community respiratory pathogens. Avelox has excellent coverage against Gram-positive cocci while retaining good activity against Gram-negative bacteria and atypical pathogens. Avelox has proven efficacious in the treatment of complicated skin and skin structure infections. In addition, it has good in-vitro activity against anaerobes.
Generic Avelox does not work for viral infections (for example, the common cold). Generic Avelox works by stopping the life cycle of bacteria.
|| Top || Working Mechanism of Avelox
Generic Avelox works by entering bacterial cells and inhibiting the action of two bacterial enzymes, called topoisomerase II (DNA-gyrase) and IV. These enzymes are involved in the replication and repair of bacterial genetic material (DNA); processes that are needed for the bacteria to multiply.
The inhibition of these bacterial enzymes and hence the interference with the bacterial DNA, ultimately results in Avelox killing the bacteria.
|| Top ||
Avelox Dose Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Avelox.
Excess Dose of Avelox
Generic Avelox in excess dose may show symptoms such as include seizures, poor coordination, tremors, sleepiness, vomiting and diarrhea.
Conditions for Storage of Avelox
Store Avelox at room temperature away from moisture and heat.
Potencies of Avelox
Avelox Tablets
Avelox 400 mg.
|| Top ||
Food and Drug Interactions with Avelox
- Generic Avelox must not be taken in by people taking any of the following medicines, as this may increase the risk of abnormal heart rhythms (prolonged QT interval on the heart monitoring trace or ECG):
- medicines to treat abnormal heart rhythms, e.g. amiodarone, procainamide, quinidine, disopyramide, sotalol
- tricyclic antidepressants, e.g. amitriptyline, imipramine
- certain antipsychotics, e.g. thioridazine, chlorpromazine, sertindole, haloperidol, pimozide
- the antihistamines astemizole, terfenadine or mizolastine
- certain antimicrobials, e.g. intravenous erythromycin or pentamidine
- antimalarials, e.g. halofantrine, chloroquine, quinine
- cisapride.
- Generic Avelox should be used with caution in people who are taking medicines that can reduce the amount of potassium in the blood, as if low blood potassium occurs there may be an increased risk of abnormal heart rhythms. Medicines that can lower blood potassium include the following:
- corticosteroids, e.g. beclometasone, prednisolone
- diuretics, e.g. bendrofluazide, frusemide
- beta agonist bronchodilators, e.g. salbutamol.
- An interval of about six hours should be left between taking Avelox and any of the following:
- antacids containing magnesium or aluminium
- didanosine tablets
- sucralfate
- preparations containing iron or zinc.
|| Top ||
Contraindications with Avelox
Avelox is contraindicated in the following
- Abnormal heart rhythm seen on the heart monitoring trace (ECG) as a 'prolonged QT interval'
- Allergy to other quinolone-type antibiotics
- Pregnancy & Breastfeeding
- Children and growing adolescents
- Decreased liver function
- Heart failure
- History of symptomatic irregular heart beats (symptomatic arrhythmias)
- History of tendon disorders related to previous use of a quinolone-type antibiotic
- Imbalance of the salts in the blood, particularly low blood potassium levels (hypokalaemia)
- People receiving kidney dialysis
- Significantly decreased kidney function
- Slow heart rate (bradycardia)
|| Top || Precautions with Avelox
Avelox should be used with caution in
- Elderly people
- Family history of a lack of the enzyme G6PD in the blood (G6PD deficiency)
- History of epilepsy
- Lack of the enzyme G6PD in the blood (G6PD deficiency)
- People being treated with corticosteroids, e.g. prednisolone
- People with an increased tendency to have seizures (fits)
- People with conditions predisposing them to abnormal heart rhythms (arrhythmias)
|| Top ||
Adverse effects with Avelox
The adverse effects associated with Avelox are
- Headache
- Difficulty in sleeping (insomnia)
- Confusion
- Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain
- Abnormal heart beats (arrhythmias)
- Indigestion (dyspepsia)
- Seizures (convulsions)
- Alteration in results of liver function tests
- Balance problems involving the inner ear (vertigo)
- Dizziness
- Alteration in taste
- Sleepiness (somnolence)
- Weakness or loss of strength (asthenia)
- Chest pain
- Vaginal thrush (candidiasis)
- Anxiety
- Pain in the muscles and joints
- Rash or itching
|| Top ||
|
|
